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Scott C Anderson's avatar

Walton, it's understudied, but there is evidence for microbial dysfunction in OCPD as well as OCD. More studies, please!

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Walton Wang's avatar

Thanks so much—that’s super helpful. Good to know there’s emerging evidence in OCPD too. Understudied but promising—+1 to more studies!

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Brooke Anderson's avatar

I need to read this paper!! Are you saying that even with the same genetic markers for OCD, certain microbes alter the risk for OCD symptoms/diagnosis?

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Walton Wang's avatar

Loved this piece—clear and nuanced.

Quick question: do we have any evidence that OCPD (obsessive-compulsive personality traits) is influenced by the gut–brain axis the way OCD appears to be? I know OCPD ≠ OCD (trait-level rigidity/perfectionism vs. obsessions+compulsions), but I’m curious whether microbiome/inflammation/serotonergic pathways show up in OCPD too—or if this area is mostly unstudied.

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